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Cancer Clinical Trials in Ireland

Active Cancer Trials Ireland’s trials are listed below per Disease Type. [Status as of 14-Oct-2016]

For Trials due to open very shortly, please click here

If you would like to find out more about any of these trials, please speak with your doctor.   

Breast Cancer

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
************ 
  NICHE STUDY
************ 
Locally Advanced and/or Metastatic  with Germline BRCA Mutations
TRIO 023 \ BMN 673-301 EMBRACA Study \ ICORG 14-01 Randomised Study comparing BMN 673 (a PARP Inhibitor) against Physician's choice Dublin
Mater, St Vincent's

Galway
Limerick
HER2+ Metastatic Breast Cancer (MBC) NALA \ ICORG 14-21 Randomised study to assess Neratinib plus Capecitabine versus the combination of Lapatinib plus Capecitabine Dublin
Mater, St. James's, St. Vincent's

Cork University Hospital
Galway
HER2-
Metastatic Breast Cancer (MBC)  
16298 Radium 223 in BC \ ICORG 14-22 Randomised study to assess efficacy and safety of radium-223 dichloride in subjects with human epidermal growth factor receptor 2 negative (HER2 negative) hormone receptor positive breast cancer with bone metastases treated with hormonal treatment background therapy Dublin
Mater, SLRON

Cork University
Galway
HER2 Normal Penelope B \ ICORG 14-11 Study to assess Palbociclib in patients with hormone‐receptor‐positive, HER2‐normal primary breast cancer with high relapse risk after neoadjuvant chemotherapy
Dublin
Beaumont, Mater, St James's, St Vincent’s
 
Cork
Bons Secours
Cork University
 
Galway
Limerick
Waterford
Hormone Positive Metastatic Breast Cancer (MBC) GEICAM FLIPPER \ ICORG 15-16 Study to compare Fulvestrant+Placebo versus Fulvestrant+Palbociclib as First Line Therapy for Postmenopausal Women With Hormone Receptor Positive Metastatic Breast Cancer
Dublin
Beaumont, Mater, St James's, St Vincent’s
 
Cork
Bons Secours
 
Galway
Limerick
Waterford
 Early Stage BC NSABP B-51 \ RTOG 1304 \ICORG 15-03
Standard or Comprehensive Radiation Therapy in Treating Patients With Early-Stage Breast Cancer Previously Treated With Chemotherapy and Surgery
Dublin
SLRON

Galway
Metastatic Triple Negative Breast Cancer (mTNBC) Keynote-119 \ ICORG 15-33 Randomised study to assess Pembrolizumab versus Single Agent Chemotherapy per Physician’s Choice
Dublin
Beaumont, Mater
HER2+ Metastatic Breast Cancer (MBC) PantHER / CTRIAL-IE (ICORG) 15-02 Study to assess copanlisib in combination with trastuzumab in pre-treated reccurent or metastatic HER2-positive breast. 
Dublin
Beaumont, St Vincent's  
 
Galway                                       

 

Early Stage Breast Cancer PALLAS / CTRIAL-IE (ICORG) 15-17 Study to compare palbociclib with standard adjuvant endocrine therapy versus standard adjuvant endocrine therapy alone for hormone receptor positive (HR+) / human epidermal growth factor receptor 2 (HER2)-negative early breast cancer.
Dubin
Beaumont, St Vincent's, Mater, St James's
 
Cork University
Waterford
Locally Advanced Breast Cancer NeoTRIPaPDL1 / CTRIAL-IE (ICORG) 15-49 Study to assess PDL1-directed antibody in Triple Negative Locally Advanced Breast Cancer undergoing treatment with nab-paclitaxel and carboplatin.
Dublin
Beaumont, St Vincent's, Mater, St James's
 
Cork University
Galway
Waterford
NTRK fusion-positive breast cancer LOXO-TRK-15002 Navigate / CTRIAL-IE (ICORG) 15-42 Study to assess oral TRK Inhibitor LOXO-101 in subjects with NTRK fusion-positive tumours.
Dublin
St Vincent's
Early Stage Breast Cancer POSITIVE / CTRIAL-IE (ICORG) 16-20 Study to evaluate the pregnancy outcomes and safety of interrupting endocrine therapy for young women with endocrine responsive breast cancer who desire pregnancy.
Dublin
St Vincent's
 
Waterford
Advanced Breast Cancer MO29518 / CTRIAL-IE (ICORG) 16-64 Study to assess atezolizumab in advanced solid tumours.
Dublin
St Vincent's, St James's
 
 

CNS Cancer

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
Gliobastoma M13-813 INTELLANCE 1 \ ICORG ICORG 15-28 Randomised Study to assess ABT-414 alone or ABT-414 plus temozolomide versus lomustine for recurrent glioblastoma Dublin
Beaumont
 
Gliobastoma M14-483 INTELLANCE 2 \ ICORG 15-29  Randomised study to assess ABT-414 alone or ABT-414 plus temozolomide versus lomustine for recurrent glioblastoma Dublin
Beaumont

Cork University


Gastrointestinal Cancer   

Patients With
Study Name
Purose of Study
Hospitals Taking Part
Recurrent and Metastatic Colon Cancer BMS CA209-142 \ ICORG 14-19 Study comparing Nivolumab and Nivolumab Plus Ipilimumab
Dublin
Beaumont, St Vincent’s

Galway
Metastatic Colorectal Cancer STRATEGIC-1 \ ICORG 14-20 Multi-Line Therapy Trial in Unresectable Metastatic Colorectal Cancer
Dublin
Mater, St James's,
St Vincent’s, Tallaght

Cork
Bons Secours,
Cork Univeristy

Galway

Waterford
Stage IV Colorectal Cancer MK 3475-177\KEYNOTE-177 \ CTRIAL-IE 16-28 Randomised study to compare Pembrolizumab (MK-3475) vs. Chemotherapy in patients with MSI-H or dMMR Stage IV Colorectal Carcinoma
Dublin
St James's, 
Tallaght
 
Hepatocellular Cancer Exelixis Celestial \ ICORG 14-17  Study to assess Cabozantinib in patients previously treated with Sorafenib Dublin
Mater
Oesophageal/Gastric Cancer
Randomised study comparing Chemotherapy (MAGIC Regimen) versus Chemoradiation (CROSS Protocol)
Dublin
SLRON Beaumont

Cork
Cork University
 
Galway
Locally Advanced Rectal Cancer TRI-LARC \ CTRIAL-IE (ICORG) 12-38 Randomised study comparing standard radiotherapy versus Intensity Modulated readiotherapy Dublin
St Luke's Centres (Beaumont and St James)
 

 Genito-Urinary Cancer

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
High Risk Prostate Cancer
Abiraterone \ ICORG 13-23 Study evaluating Neo-adjuvant (pre-radical radiotherapy) Abiraterone acetate (plus prednisolone) and Gonadotropin-releasing hormone (GnRh)
Dublin
St Luke's

Cork University
Galway
Localised Prostate Cancer
Randomised Study of Enzalutamide in androgen deprivation therapy with radiation therapy
Dublin
St Luke's, Mater

Cork University
Galway
Whitfield, Waterford
Metastatic Prostate Cancer PEACE-1 \ ICORG 13-09 Randomised Study comparing Androgen Deprivation Therapy with or without local Radiotherapy, with or without abiraterone acetate and prednisone Dublin
Mater, St Luke's, St Vincent's, Tallaght

Cork University
Galway
Metastatic Prostate Cancer Radium&Enza \ ICORG 13-21 Study evaluating the combination of radium-223 with enzalutamide Dublin
Mater, St Luke's, St Vincent's

Cork University
Galway
Metastatic Prostate Cancer ENZAMET \ ICORG 14-06 Randomised Study of Enzalutamide in first line androgen deprivation therapy Dublin
Beaumont, Mater, St James's, St Vincent's, Tallaght

Galway
Waterford
       

 

Gynaecology Cancer 

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
Cervical Cancer
SHAPE Study \ ICORG 14-02
Randomised study comparing Radical Hysterectomy and Pelvic Node Dissection versus Simple Hysterectomy and Pelvic Node Dissection
Dublin
St James’s
Endometrial Cancer
Randomised study assessing Pelvic Radiotherapy Using Either IMRT or 3-Dimensional Planning
Dublin
Beaumont, St Luke’s
Ovarian Cancer
Randomised study comparing Avelumab alone to Avelumab plus Pegylated Liposomal Doxorubicin(PLD) and to PLD alone
Dublin
Mater, St James's
Ovarian, Fallopian tube or peritoneal cancer ICON 8B \ ICORG 11-29 Randomised study assessing chemotherapy and bevacizumab versus either therapy alone in women with newly diagnosed high-riskstage III-IV epithelial ovarian, fallopian tube or primary peritoneal cancer Dublin
Mater, St James’s

Bon Secours (Cork)
Galway
Waterford
 
 

Haematology & Lymphoma Cancer  

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
B-Cell Lymphoma
Randomised study comparing Lenalidomide and R-CHOP chemotherapy versus Placebo and R-CHOP chemotherapy
Dublin
Mater, St James’s

Cork University
Higher-Risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Low-Blast Acute Myelogenous Leukemia
Ransomised Study to assess the Efficacy and Safety of Pevonedistat Plus Azacitidine Versus Single-Agent Azacitidine in Patients With Higher-Risk Myelodysplastic Syndromes, Chronic Myelomonocytic Leukemia, and Low-Blast Acute Myelogenous Leukemia
Dublin
Mater, Tallaght

Galway   
 

Myelodysplastic Syndrome (MDS)
Randomised Study comparing Rogosertib versus Physicians Choice in MDS After Failing A Hypermethylating Agent
Dublin
Tallaght

Cork University
Galway
Waterford
Hodgkin Lymphoma or Anaplastic Large Cell Lymphoma ARROVEN PASS \ ICORG 15-09 Observational study of the safety of Brentuximab Vedotin Dublin
Beaumont, Mater, St James's,

Cork University
Galway
Refractory Indolent B-cell Non-Hodgkin's Lymphoma
(iNHL)
CHRONOS 2 \ ICORG 15-37 Study assessing Copanlisib in Rituximab-refractory Indolent B-cell Non-Hodgkin's Lymphoma Dublin
Beaumont
Relapsed Indolent B-cell Non-Hodgkin's Lymphoma
(iNHL)
CHRONOS 3 \ ICORG 15-38 Study assessing Copanlisib and Rituximab in Relapsed Indolent B-cell Non-Hodgkin's Lymphoma Dublin
Beaumont, Mater, St James's, St Vincent's

Galway
Relapsed or Refractory Multiple Myeloma (MM) OPTIMISMM \ ICORG 15-10 Study comparing the efficacy of the combination of Pomalidomide, Bortezomib and Dexamethasone to the combination of Bortezomib and Dexamethasone Dublin
St James's, Mater

Galway  
Smoldering Multiple Myeloma
ECOG E3A06 Study - Randomised Study of Lenalidomide Versus Observation Alone
Dublin
Beaumont, Mater, St James’s, St Vincent’s, Tallaght
 
Cork
Bon Secours
Cork University
 
Galway
Letterkenny
Limerick
Sligo
Waterford

 
Head & Neck Cancer 

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
Recurrent or Metastatic Squamous Cell Carcinoma

BMS CA209- 714 / CTRIAL-IE 16-54                    
Study of Nivolumab in Combination with Ipilimumab Versus Nivolumab in Combination with Ipilimumab Placebo in Patients with Reccurent or Metastatic Squamous Cell Carcinoma of the Head and Neck
Dublin
St James's Hospital

 
Lung Cancer 

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
Oligometastatic Disease UPCI 10-028 \ CTRIAL-IE (ICORG) 15-05
Radiosurgery for Patients Recurrent Oligometastatic Disease
Dublin
Beacon
Early Stage
Non-Small Cell Lung Cancer
ETOP EORTC 1416 PEARLS Study \ ICORG 15-40 Randomised Study for patients with Stage IB/II-IIIA non-small cell lung cancer who have undergone surgical resection with or without adjuvant chemotherapy that will either be treated with pembrolizumab or placebo Dublin
Mater, St James’s, St Vincent's

Cork
Bon Secours
Cork University

Limerick
Waterford

Chemotherapy-Naïve Stage IV or Recurrent Non-Small Cell Lung Cancer
BMS CA209-227 \ ICORG 15-27 Randomised study comparing Nivolumab, or Nivolumab Plus Ipilimumab, or Nivolumab Plus Platinum Doublet Chemotherapy Versus Platinum Doublet Chemotherapy in Patients With Chemotherapy-Naïve Stage IV or Recurrent Non-Small Cell Lung Cancer Dublin
Beaumont, St James’s

Galway
Limerick
Advanced Non-Small Cell Lung Cancer ETOP Splendour \ ICORG 12-53 Survival Improvement In Lung Cancer Induced By Denosumab Therapy

 

Dublin
Beaumont, Mater, St James’s, St Vincent's, Tallaght

Cork University
Galway
Limerick
Waterford
Locally Advanced Non-Small Cell Lung Cancer INTENSE \ CTRIAL 15-47 Study to assess dose escalations in patients with Non Small Cell Lung Cancer via intensity modulated radiation therapy (IMRT) or volume modulated arc therapy (VMAT) On hold
ED Small Cell Lung Cancer BMS CA209-451 (CheckMate-451) \CTRIAL 16-18 Study to assess Nivolumab, or Nivolumab in Combination With Ipilimumab, or Placebo in Patients With (ED-SCLC) After Completion of Platinum-based Chemotherapy
Dublin
St Vincent's, Tallaght Cork University
 
Galway
Limerick

 

       

 
Melanoma Cancer 

Patients With
Study Name
Purpose of Study
Hospitals Taking Part
Unresectable or Metastatic Melanoma
Study of Pembrolizumab + Epacadostat or Placebo in Patients With Unresectable or Metastatic Melanoma
Dublin
Beaumont, Mater Cork University
Galway University
Stage III or Stage IV Melanoma
CheckMate 401 \ ICORG 16-14 Study to assess Nivolumab Combined with Ipilimumab Followed by Nivolumab only in Patients with Stage III or Stage IV Melanoma Dublin
Mater, St Vincent’s

Cork University
Melanoma
LOXO-101 \ ICORG 15-42 Study to assess an Oral TRK Inhibitor (LOXO-101) in Patients With NTRK Fusion-Positive Tumors Dublin
St Vincent's