Trial Group - Lung

For patients with non-small cell lung cancer (NSCLC) who are unsuitable for surgery or stereotactic ablative body radiation therapy (SABR)

The primary objective of this study is to assess the safe delivery of an achievable level of dose escalation in a dose‐escalated and
intensified radiation therapy regime delivered via VMAT/IMRT and focussed on the GTV, by the
proportion of grade ≥3 toxicities per NCI‐CTCAE V4 determined to be related to radiation
therapy.

Participants with previously untreated, stage IV, metastatic non-small cell lung cancer whose tumours are PD-L1 positive (TPS ≥ 50%)

The purpose of this study is to determine the efficacy of pembrolizumab given in combination with either ipilimumab or placebo as first-line treatment in participants with metastatic non-small cell lung cancer (NSCLC). The primary hypothesis of this study is that overall survival (OS) and/or progression-free survival (PFS) is prolonged in participants who receive pembrolizumab and ipilimumab compared to those who receive pembrolizumab and placebo.

Patients with advanced stage RET-rearranged NSCLC, treated with at least one platinum based systemic chemotherapy regimen.

The primary objective is to assess the efficacy of alectinib in terms of best overall response (OR) assessed by RECIST 1.1., from the start of trial treatment across all time points until the end of trial treatment

Participants With Resectable Stage IIB or IIIA Non-small Cell Lung Cancer

To assess the efficacy and safety of Pembrolizumab (MK-3475) with platinum doublet chemotherapy as neoadjuvant/adjuvant therapy for participants With resectable stage IIB or IIIA non-small cell lung cancer.

Treatment-naïve locally advanced or metastatic non-small cell lung cancer (NSCLC)

To compare the effectiveness of atezolizumab versus single agent chemotherapy.

Extensive-stage Small Cell Lung Cancer (ED SCLC).

To evaluate if rovalpituzumab tesirine improves progression-free and overall survival.

Early stage non-small cell lung cancer (NSCLC)

The purpose of this trial is to assess whether pembrolizumab after completion of radical surgery followed by standard treatment will improve disease free survival.