About this trial
This is a translational sub-study to the main, original ICORG (CTRIAL-IE) 08-01 CADY-study and includes the:
1. Analysis of the following cardiac biomarkers: high sensitivity Troponin I (hsTnI), B-type Natriuretic Protein (BNP), N-terminal ProBNP (NT-proBNP) and Galectin-3 (Gal-3) on existing blood samples taken within the main Cady study using new, more sensitive test kits.
2. Retrospective collection of Major Adverse Cardiovascular Event (MACE) data on patients enrolled on the main study.
3. Analysis of biomarker results together with the MACE data and the existing LVEF data to assess the predictive capability of the biomarkers.
Patient Profile
No new patients will be recruited to this study. Patients who participated in the CTRIAL-IE (ICORG) 08-01 CADY study on cardiac dysfunction in HER-2 positive breast cancer patients are asked to please read this important data protection notice. In collaboration with Abbott Laboratories, Cancer Trials Ireland is conducting a follow-up sub-study to re-test stored biological samples using advanced biomarker technology and review medical records for cardiovascular outcomes. This research aims to improve the early detection of heart risks in breast cancer patients treated with Trastuzumab. Your data remains securely stored and protected with strict access controls. If you wish to learn more, withdraw consent, or exercise your data rights, click here to read the full notice.
Where’s this trial being run?
Bon Secours Cork, Cork University Hospital, Letterkenny University Hospital, Sligo University Hospital, St James’s Hospital, Tallaght University Hospital, St Vincents University Hospital, University Hospital Limerick, University Hospital Galway, University Hospital Waterford, Mater Misericordiae University Hospital, and Mater Private Hospital
Can I join this study / trial?
The first step we recommend is to talk to your doctor or the cancer trials team at your hospital. You can find contact details for cancer trials research units in Ireland here.
It’s also a good idea to print this page and bring it with you to your appointment. It can help guide the conversation and remind you of what to ask. You may also want to talk to your family or friends about your options, as they can offer support as you make decisions.
For more detailed information
Click HereQuestions?
Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | CADY Sub-Study |
|---|---|
| Number: | 08-01 |
| Full Title: | “CADY Sub-Study”: Analysis of Biomarker, Cardiotoxicity and Major Adverse Cardiovascular Events data to develop predictive models for cardiotoxicity and MACE in Breast Cancer. |
| Principal Investigator: | Prof Ray McDermott |
|---|---|
| Type: | Industry Sponsored |
| Sponsor: | Cancer Trials Ireland |
| Recruitment Started: |
Global: N/A Ireland: 10-Jun-2008 |
| Global Recruitment Target: | N/A |
|---|---|
| Ireland Recruitment Target: | 480 |