About this trial
The purpose of the trial is to determine the overall response rate among patients with advanced solid tumors harboring a fusion of NTRK1, NTRK2 or NTRK3 following treatment with LOXO-101.
It is a Phase II, multi-center, open-label study.
Patient Profile
Patients with advanced solid tumors harboring a fusion of NTRK1, NTRK2 or NTRK3.
Subjects with NTRK1, NTRK2, or NTRK3 fusion-positive cancers will be identified through molecular assays as routinely performed at Clinical Laboratory Improvement Amendments of 1988 (CLIA) or other
similarly certified laboratories.
Where’s this trial being run?
St Vincents University Hospital
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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Click HereQuestions?
Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | LOXO 101 |
|---|---|
| Number: | 15-42 |
| Full Title: | A Phase II Basket Study of the Oral TRK Inhibitor LOXO-101 in Subjects With NTRK Fusion-Positive Tumors |
| Principal Investigator: | Prof Ray McDermott (St. Vincent's University Hospital) |
|---|---|
| Type: | Industry Sponsored |
| Sponsor: | Loxo Oncology, Inc. |
| Recruitment Started: |
Global: October 2015 Ireland: September 2015 |
| Global Recruitment Target: | 226 |
|---|---|
| Ireland Recruitment Target: | 7 |