NEEDS

About this trial

The study is a multi-centre Phase 3 clinical trial to compare outcomes in patients who receive chemoradiotherapy (chemotherapy and radiotherapy) before surgery versus outcomes in patients who receive chemoradiotherapy with surveillance and oesophagectomy (if it becomes required) in patients with operable locally advanced squamous cell carcinoma (SCC) of the oesophagus.

The study is initiated, organised, and conducted by the Karolinska University Hospital. Karolinska University Hospital is an academically oriented research institution and sponsor of the study. The study is being coordinated by Cancer Trials Ireland in Ireland.

Patient Profile

This study will include 20 Irish patients and 1020 patients globally.

Patients who have been diagnosed with operable locally advanced SCC of the oesophagus will be included in this study.

Where’s this trial being run?

St James’s Hospital

Can I join this study / trial?

The first step we recommend is to talk to your doctor or the cancer trials team at your hospital. You can find contact details for cancer trials research units in Ireland here.

It’s also a good idea to print this page and bring it with you to your appointment. It can help guide the conversation and remind you of what to ask. You may also want to talk to your family or friends about your options, as they can offer support as you make decisions.

For more detailed information

Click Here

Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.

Questions

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Summary Data

Name:	NEEDS
Number:	20-36
Full Title:	NEoadjuvant chemoradiotherapy for Esophageal squamous cell carcinoma versus Definitive chemoradiotherapy with salvage Surgery as needed (NEEDS Trial)

Principal Investigator:	Prof. John Reynolds
Type:	Collaborative
Sponsor:	Karolinska University Hospital
Recruitment Started:	Global: November 2020 Ireland: February 2024

Global Recruitment Target:	1020
Ireland Recruitment Target:	20