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About this trial

The aim of this trial is to compare and evaluate two well-established standard of care treatments for cancer of the oesophagus in order to establish if one treatment is better than the other.

The two treatments in this study are:

1) Chemotherapy before and after surgery (treatment A), your doctor can choose between the modified MAGIC or FLOT regimen

2) Chemotherapy and radiotherapy before surgery (treatment B), known as the CROSS regimen

It has become more common in recent years to give either chemotherapy alone or combined with radiation therapy before surgery for these cancers. These treatments are tried and tested approaches, but they have never been compared directly. We do not know which is better, and perhaps there is no difference. Only a well-designed study such as this will answer that question and hopefully define the better approach for the future.

Patient Profile

This study is open to men and women over 18 years of age with confirmed cancer of the oesophagus or the junction between the oesophagus and the stomach (oesophago-gastric junction, OGJ), which is made up of cells of a particular type (adenocarcinoma).

About 540 patients from centres in four European countries; Ireland, the UK, Denmark and France, will take part in the study. Patients will be in the study for the duration of the treatment (Treatment A: 6-7 months, Treatment B: 3-4 months) and will be followed-up by the study team at the hospital for a minimum of 3 years after surgery (by contacting you every six-months thereafter).

Where’s this trial being run?

St James’s Hospital, St Luke’s Radiation Oncology Network @ St James’s Hospital, and St Luke’s Radiation Oncology Network @ St Luke’s Hospital

Can I join this study / trial?

The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.

Why not Print this page and bring it with you. It will help your doctor and research team advise you.

For more detailed information


Here’s a list of questions you may have for your doctor or local cancer research team.

Summary Data

Name: Neo-AEGIS
Number: 10-14
Full Title:

Neo-AEGIS (NEO-adjuvant trial in Adenocarcinoma of the oEsophagus and oesophagoGastric junction International Study): Randomised Clinical Trial of neoadjuvant and adjuvant chemotherapy (Investigator’s choice Modified MAGIC or FLOT regimen) vs. neoadjuvant chemoradiation (CROSS protocol) in adenocarcinoma of the oesophagus and oesophago-gastric junction

Principal Investigator: Prof John Reynolds (St. James's Hospital)
Type: In-House

Cancer Trials Ireland.

Recruitment Started: Global: January 2013
Ireland: January 2013
Global Recruitment Target: 540
Ireland Recruitment Target: 180