About this trial

The purpose of this trial is to investigate whether surgery alone or surgery plus radiotherapy is better at treating atypical meningiomas.

Meningiomas are brain tumours arising from the linings of the brain. Most of these tumours are benign (meaning non-cancerous) and can be treated with surgery alone. Very rarely these tumours are malignant (cancerous) and need treatment with both surgery and radiotherapy.

There is a third group, called atypical meningiomas that fall between the benign and malignant group. Following surgery, there is still a chance that atypical meningioma’s can regrow. Currently it is not know whether surgery alone or surgery followed by radiotherapy is more effective in treating these tumours.

The study will help hospitals and doctors decide which is the most effective treatment to use in the future.

Patient Profile

Patients who have had surgery to remove an atypical meningioma, which is a brain tumour arising from the linings of the brain.

In this trial it is surgery alone and surgery plus radiotherapy that are being tested, so people taking part will be split equally into 2 groups by random chance:

Group A: Patients will receive surgery plus radiotherapy

Group B: Patients will receive surgery alone

Participants will be allocated to one of the 2 groups above. This will be done randomly by a computer.

Where’s this trial being run?

Beaumont Hospital and St Luke’s Radiation Oncology Network @ Beaumont Hospital

Can I join this study / trial?

The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.

Why not Print this page and bring it with you. It will help your doctor and research team advise you.

For more detailed information


Here’s a list of questions you may have for your doctor or local cancer research team.

Summary Data

Name: ROAM
Number: 15-41
Full Title:

Radiation versus Observation following surgical resection of Atypical Meningioma: a randomised controlled trial.

Principal Investigator: Dr David Fitzpatrick (St. Luke's Hospital)
Type: Collaborative

The study is being organised by The Walton Centre NHS Foundation Trust in Liverpool, UK.

The study is sponsored in the Republic of Ireland by Cancer Trials Ireland.

Recruitment Started: Global: Q2 2016
Ireland: Q1 2018
Global Recruitment Target: 190
Ireland Recruitment Target: 8