About this trial
This is a multicenter, randomized, double-blind, placebo-controlled study of niraparib plus pembrolizumab versus placebo plus pembrolizumab as maintenance therapy in participants with advanced or metastatic non-small cell lung cancer (NSCLC) who have achieved stable disease (SD), partial response (PR), or complete response (CR) following completion of standard of care first-line platinum-based induction chemotherapy with pembrolizumab.
Patient Profile
Advanced / Metastatic Non-Small Cell Lung Cancer who have achieved stable disease (SD), partial response (PR), or complete response (CR) following completion of standard of care first-line platinum-based induction chemotherapy with pembrolizumab.
Where’s this trial being run?
Cork University Hospital, St James’s Hospital, and University Hospital Limerick
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | ZEAL-1L |
|---|---|
| Number: | 21-26 |
| Full Title: | A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study Comparing Niraparib Plus Pembrolizumab Versus Placebo Plus Pembrolizumab as Maintenance Therapy in Participants Whose Disease Has Remained Stable or Responded to First-Line Platinum Based Chemotherapy With Pembrolizumab for Stage IIIB/IIIC or IV Non-Small Cell Lung Cancer (ZEAL-1L) |
| Principal Investigator: | Dearbhaille Collins |
|---|---|
| Type: | Industry Sponsored |
| Sponsor: | GlaxoSmithKline |
| Recruitment Started: |
Global: Ireland: |
| Global Recruitment Target: | 650 |
|---|---|
| Ireland Recruitment Target: | 9 |