All of the following trials are conducted at Our Lady’s Children’s Hospital, Crumlin.

Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
Interfant 06 16-53 Collaborative November 2014 Dr Owen Smith

International collaborative treatment protocol for Infants under one year with Acute Lymphoblastic or Biphenotypic Leukemia.

Crumlin's Children Hospital (4)
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EURO-Ewing 2012 16-52 Collaborative April 2015 Dr Cormac Owens

International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours

1
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Registry 16-49 Collaborative April 2015 Dr Cormac Owens

Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement (SCI).

2
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EWOG-SAA-2010 16-46 Collaborative April 2012 Dr Owen Smith

Genetic & Immunological Characterisation of Acquire Severe Aplastic Anaemia (SAA) in Children & Adolescents

19
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EU-RHAB 16-44 Collaborative October 2012 Dr Michael Capra

European Rhabdoid Registry. A Multinational registry for rhabdoid tumours of any anatomical site

7
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
OLCHC Tumour Bank 16-43 Collaborative October 2012 Not Applicable

Procedure agreed for Tumour tissue and matched blood-DNA banking at OLCHC.

122
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
Renal IMPORT 16-42 Collaborative February 2012 Dr Jane Pears

Improving Population Outcomes for Renal Tumours of Childhood.

17
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Lines 16-41 Collaborative February 2016 Dr Cormac Owens

European Low and Intermediate Risk Neuroblastoma – A SIOPEN Study.

2
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Beacon 16-40 Collaborative May 2014 Dr Cormac Owens

A randomised phase IIb trial of trial of VEGF Inhibitor added to Temozolomide ± IrinOtecan for children with refractory/relapsed Neuroblastoma.

5
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL LTI Study 16-39 Collaborative August 2016 Dr Cormac Owens

A Phase I/II Dose Schedule Finding Study of Monoclonal Antibody Continuous Infusion Combined With Subcutaneous Aldesleukin (IL-2) in Patients with Primary or Relapsed Neuroblastoma.

8