All of the following trials are conducted at Our Lady’s Children’s Hospital, Crumlin.

Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EURO-Ewing 2012 16-52 Collaborative April 2015 Dr Cormac Owens

International Randomised Controlled Trial for the Treatment of Newly Diagnosed Ewing’s Sarcoma Family of Tumours

1
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Registry 16-49 Collaborative April 2015 Dr Cormac Owens

Prospective Study Registry of Peripheral Neuroblastic Tumours Presenting with Spinal Canal Involvement (SCI).

2
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EWOG-SAA-2010 16-46 Collaborative April 2012 Dr Owen Smith

Genetic & Immunological Characterisation of Acquire Severe Aplastic Anaemia (SAA) in Children & Adolescents

19
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EU-RHAB 16-44 Collaborative October 2012 Dr Michael Capra

European Rhabdoid Registry. A Multinational registry for rhabdoid tumours of any anatomical site

7
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
OLCHC Tumour Bank 16-43 Collaborative October 2012 Not Applicable

Procedure agreed for Tumour tissue and matched blood-DNA banking at OLCHC.

122
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
Renal IMPORT 16-42 Collaborative February 2012 Dr Jane Pears

Improving Population Outcomes for Renal Tumours of Childhood.

17
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Lines 16-41 Collaborative February 2016 Dr Cormac Owens

European Low and Intermediate Risk Neuroblastoma – A SIOPEN Study.

2
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL Beacon 16-40 Collaborative May 2014 Dr Cormac Owens

A randomised phase IIb trial of trial of VEGF Inhibitor added to Temozolomide ± IrinOtecan for children with refractory/relapsed Neuroblastoma.

5
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL LTI Study 16-39 Collaborative August 2016 Dr Cormac Owens

A Phase I/II Dose Schedule Finding Study of Monoclonal Antibody Continuous Infusion Combined With Subcutaneous Aldesleukin (IL-2) in Patients with Primary or Relapsed Neuroblastoma.

8
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
EWOG-MDS-2006 16-37 Collaborative January 2012 Drs Aengus O’Marcaigh / Prof. Owen Smith

Prospective non-randomised multi-center study for epidemiology and characterisation of Myelodysplastic Syndrome (MDS) and Juvenile Myelomonocytic Leukemia (JNML) in childhood.

3