All of the following trials are conducted at Our Lady’s Children’s Hospital, Crumlin.

Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
NBL NK Study (TCD) In-House To be confirmed
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
LCH IV 2011-001699-20 Collaborative To be confirmed Dr Jane Pears (OLCHC)
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
MONTE Biomarker Study (RCSI) 19-04 Collaborative To be confirmed Dr. Cormac Owens (OLCHC)
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
MAPPYACTS 18-19 Collaborative October 2018 Dr Cormac Owens

A Prospective, Multicentre study to stratify targeted therapies adapted to molecular profiling of relapsed or refractory paediatric tumours.

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
ITCC 054 18-24 Collaborative 2018 Dr Owen Smith

A phase I/II study of Bosutinib in pediatric patients with Chronic Myeloid Leukemia who are resistant or intolerant to at least one prior Tyrosine Kinase Inhibitor therapy, ITCC-054.

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
PHITT 18-17 Collaborative 2018 Michael Capra

Paediatric Hepatic International Tumour Trial.

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
ITCC 059 18-16 Collaborative 2018 Dr Owen Smith

A Phase 1 study of Inotuzumab Ozogamycin as a single agent and in combination with chemotherapy for paediatric CD22-Positive ALL

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
Mye Child 16-82 Collaborative August 2018 Dr Owen Smith

International Randomised Phase III Clinical Trial in Children With Acute Myeloid Leukaemia (Myechild01).

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
LOXO TRK 15003 18-36 Industry Sponsored Oct 2018 Dr Cormac Owens

A Phase 1/2 Study of the Oral TRK Inhibitor LOXO-101 in Pediatric Patients with Advanced Solid or Primary Central Nervous System Tumors.

Not Available
Name No. Type Date Opened Principal Investigator(s) Title No. on this trial
Interfant 06 16-53 Collaborative November 2014 Dr Owen Smith

International collaborative treatment protocol for Infants under one year with Acute Lymphoblastic or Biphenotypic Leukemia.

Crumlin's Children Hospital (4)