About this trial
The Phase 2 study has now closed to accrual.
The Phase 3 portion of the study compares the efficacy of Adagrasib in combination with pembrolizumab versus pembrolizumab plus chemotherapy in patients with unresectable, locally advanced or metastatic nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS
Patient Profile
Histologically confirmed diagnosis of unresectable or metastatic squamous or nonsquamous NSCLC with KRAS G12C mutation and PD-L1 TPS >=50%
Where’s this trial being run?
Beaumont Hospital and St James’s Hospital
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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Here’s a list of questions you may have for your doctor or local cancer research team.
QuestionsSummary Data
| Name: | Krystal-7 |
|---|---|
| Number: | 22-07 |
| Full Title: | A Phase 2 Trial of MRTX849 Monotherapy and in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation |
| Principal Investigator: | Dr Jarushka Naidoo |
|---|---|
| Type: | Industry Sponsored |
| Sponsor: | Mirati Therapeutics |
| Recruitment Started: |
Global: Yes Ireland: On Hold |
| Global Recruitment Target: | 250 |
|---|---|
| Ireland Recruitment Target: | 4 |