Krystal-7

About this trial

This is a Phase 2 Trial of MRTX849 on its own and in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer (NSCLC) with KRAS G12C Mutation. KRAS G12C is a mutation which occurs in some cases of NSCLC. MRTX849 is an inhibitor of this mutation, which means that it blocks its activity. Pembrolizumab is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2.

Patient Profile

There will be 3 cohorts of patients, all of whom have KRAS G12C mutation, have advanced or metastatic Non small cell lung cancer, and are candidates for first-line treatment.

Where’s this trial being run?

Beaumont Hospital

Can I join this study / trial?

The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.

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For more detailed information

Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.


Summary Data

Name: Krystal-7
Number: 22-07
Full Title:

A Phase 2 Trial of MRTX849 Monotherapy and in Combination with Pembrolizumab in Patients with Advanced Non-Small Cell Lung Cancer with KRAS G12C Mutation

Principal Investigator: Dr Jarushka Naidoo
Type: Industry Sponsored
Sponsor:

Mirati Therapeutics

Recruitment Started: Global: Yes
Ireland: Yes
Global Recruitment Target: 250
Ireland Recruitment Target: 4