DSSG Group: Breast

breast cancer patients undergoing a mastectomy

To investigate the use of the two cutting and sealing devices currently used in mastectomy, LigaSure™ versus monopolar diathermy. At this time, the device that is utilised is the surgeons own preference.

triple negative breast cancer (TNBC)

The purpose of this study is to compare the efficacy of olaparib (MK-7339) plus pembrolizumab (MK-3475) with chemotherapy plus pembrolizumab after induction with first-line chemotherapy plus pembrolizumab in triple negative breast cancer (TNBC).

high-risk, estrogen receptor-positive, human epidermal growth factor receptor 2-negative (ER+, HER2-) early stage breast cancer

The purpose of this trial is to evaluate the efficacy and safety of nivolumab versus placebo in combination with neoadjuvant (pre-surgery) chemotherapy and adjuvant (post-surgery) endocrine therapy

Newly Diagnosed Breast Cancer

The purpose of this study is to assess the efficacy and safety of pembrolizumab in combination with pre-surgery chemotherapy and post-surgery endocrine therapy in the treatment of adults who have high-risk early-stage ER+/HER2- breast cancer.

Early stage breast cancer

This study will evaluate the efficacy, safety, and pharmacokinetics of adjuvant atezolizumab.

Breast cancer

The purpose of this trial is to examine the function of different genes and proteins, previously identified to be of interest, and identify new ones, as well as the means by which they interact and differ between cancer cells.