Trial Group - Gynaecological

Ovarian cancer

The purpose of this study is to investigate if two medications; Rucaparib and Nivolumab used together or separately are better than the current best available treatment for patients who have had platinum-based chemotherapy for ovarian cancer.

Cervical cancer

The purpose of the study is to investigate if Tisotumab Vedotin (HuMax®-TF-ADC) is safe and has an additive effect when used with other anti-cancer medications in the treatment of recurrent or advanced cervical cancer.

Advanced endometrial cancer

The purpose of this study is to assess if lenvatinib used with pembrolizumab are safe and effective in comparison to the best current available treatment.

Early stage endometrial cancer

The purpose of this study is to look at rates of vaginal recurrence in patients treated after surgery for their endometrial cancer with either external beam radiation therapy, brachytherapy or no additional treatment, based on a molecular test,in the investigational molecular arm or with brachytherapy in the standard arm.

newly diagnosed or a recurrent ovarian cancer

The study aims to assess whether it is feasible to routinely test all women with a newly diagnosed or a recurrent ovarian cancer for a mutation in the BRCA1 and BRCA2 genes when they present to the oncology clinic, using both tumour and blood samples.

Ovarian Cancer

The purpose of the trial is to investigate weekly chemotherapy and Bevacizumab in Advanced Ovarian Cancer.

Endometrial cancer

The purpose is to compare conventional radiation techniques (3-dimensional) with the newer but established Intensity Modulated Radiation Therapy (IMRT) in patients who have had surgery for endometrial cancer.