DSSG Group: Gynaecological

High-Risk Locally advanced cervical carcinoma

To compare the use of Chemoradiotherapy with or without Pembrolizumab for the treatment of High-risk Locally Advanced Cervical Cancer

Platinum Resistant epihtelial Ovarian cancer, primary peritoneal cancer or fallopian tube cancer.

The study objectives are to evaluate the safety, antitumor activity, and pharmacokinetics of tisotumab vedotin (TV) for patients with epithelial ovarian cancer, primary peritoneal cancer, or fallopian tube cancer that has relapsed within 6 months of the completion of platinum-based treatment and determined to be platinum resistant.

Early stage endometrial cancer

The purpose of this study is to look at rates of vaginal recurrence in patients treated after surgery for their endometrial cancer with either external beam radiation therapy, brachytherapy or no additional treatment, based on a molecular test,in the investigational molecular arm or with brachytherapy in the standard arm.