
About this trial
NeoCOAST-2 is a Phase 2, open-label, multicentre, randomised, two-arm study of
durvalumab + monalizumab / oleclumab + CTX. The study is intended to assess the safety and efficacy of perioperative treatment with Durvalumab in combination with Oleclumab, Monalizumab or AZD0171 and platinum doublet chemotherapy; or MEDI5752 in combination with platinum doublet chemotherapy or datopotamab deruxtecan (Dato-DXd) in combination with durvalumab and single agent platinum chemotherapy in participants with resectable, early-stage non-small cell lung cancer.
Patient Profile
- Newly diagnosed and previously untreated NSCLC.
- Resectable, Stage IIA to Stage IIIA (per IASLC Staging).
- ECOG PS 0-1.
- Tumour samples must be available or obtainable.
- Surgery may be lobectomy, sleeve resection or bilobectomy, no pneumonectomy, segmentectomies or wedge resection.
- FEV1 of 1.0 L and DLCO >40%
Where’s this trial being run?
Beaumont Hospital, St James’s Hospital, University Hospital Galway, and Mater Misericordiae University Hospital
Can I join this study / trial?
The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.
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QuestionsSummary Data
Name: | 22-23 NeoCOAST-2 |
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Number: | 22-23 |
Full Title: | A Phase II Open-label, Multicentre, Randomised Study of Neoadjuvant and Adjuvant Treatment in Patients With Resectable, Early-stage (II to IIIA) Non-small Cell Lung Cancer |
Principal Investigator: | Prof Jarushka Naidoo |
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Type: | Industry Sponsored |
Sponsor: | AstraZeneca |
Recruitment Started: |
Global: Yes Ireland: Yes |
Global Recruitment Target: | 350 |
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Ireland Recruitment Target: | 15+ |