Cancer Trials Ireland > Cancer Trials > Lung > 22-23 NeoCOAST-2

22-23 NeoCOAST-2

About this trial

NeoCOAST-2 is a Phase 2, open-label, multicentre, randomised, two-arm study of
durvalumab + monalizumab / oleclumab + CTX. The study is intended to assess the safety and efficacy of perioperative treatment with Durvalumab in combination with Oleclumab, Monalizumab or AZD0171 and platinum doublet chemotherapy; or MEDI5752 in combination with platinum doublet chemotherapy or datopotamab deruxtecan (Dato-DXd) in combination with durvalumab and single agent platinum chemotherapy in participants with resectable, early-stage non-small cell lung cancer.

Patient Profile

  1. Newly diagnosed and previously untreated NSCLC.
  2. Resectable, Stage IIA to Stage IIIA (per IASLC Staging).
  3. ECOG PS 0-1.
  4. Tumour samples must be available or obtainable.
  5. Surgery may be lobectomy, sleeve resection or bilobectomy, no pneumonectomy, segmentectomies or wedge resection.
  6. FEV1 of 1.0 L and DLCO >40%

Where’s this trial being run?

Beaumont Hospital, St James’s Hospital, University Hospital Galway, and Mater Misericordiae University Hospital

Can I join this study / trial?

The first thing you do is to talk to your doctor and/or the cancer trials research team in your hospital. The contact details for the cancer trials research units in Ireland is here.

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For more detailed information

Questions?

Here’s a list of questions you may have for your doctor or local cancer research team.

Summary Data

Name: 22-23 NeoCOAST-2
Number: 22-23
Full Title:

A Phase II Open-label, Multicentre, Randomised Study of Neoadjuvant and Adjuvant Treatment in Patients With Resectable, Early-stage (II to IIIA) Non-small Cell Lung Cancer
Principal Investigator: Prof Jarushka Naidoo
Type: Industry Sponsored
Sponsor:

AstraZeneca
Recruitment Started: Global: Yes
Ireland: Yes
Global Recruitment Target: 350
Ireland Recruitment Target: 15+